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New milestone of 3D bioprinting : magnesium bone tissue auto- repair

DateTime: 2018-07-06
浏览次数: 84

New milestone of 3D bioprinting : magnesium bone tissue auto- repair

Recently, the "magnesium-containing degradable polymer bone repair material" developed by the research team of the Institute of Translational Medicine Research and Development of the Institute of Advanced Medical Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences was listed in the latest issue of "Announcement of Results of Special Approval Applications for Innovative Medical Devices" issued by the State Food and Drug Administration (CFDA) Medical Device Technology Review Center. This is the second product approved by CFDA for innovative medical devices in the field of orthopedics in Shenzhen. It is also the first hard tissue bone repair product approved by Shenzhen in this field. The relevant public notice ended on June 27.

Bones exist like " tough guys" in human tissues, however, although human bones have the ability to regenerate, autogenous repair is extremely limited.  If the defect is large, it needs to rely on auxiliary means to " match up". The non-animal artificial bone repair materials can be roughly divided into four categories: bioglass, calcium phosphate, calcium sulfate, and hydroxyapatite, their compositions are similar to those of human bone tissues and have good biological safety. However, the degradation performance and structure of these products are difficult to control.

The magnesium-containing degradable polymer bone repair material developed by the team can control the overall degradation of the product by wrapping tricalcium phosphate and magnesium metal particles with degradable polymer materials. The product uses 3d printing to control the physical structure of the product and the ordered distribution of tricalcium phosphate and magnesium metal in the product, and is a degradable porous bone repair and filling product. the mechanical strength of the product matches with the bone growth requirement, and is suitable for filling regular or irregular bone defect parts caused by diseases and wounds, and promotes the healing of the defect parts and the regeneration of new bones.  According to the team, the design and manufacturing technology of this product is at the leading level in the world and has significant clinical application value. it is an important breakthrough in the field of 3d printed biological materials and a new milestone in the application of technology to the ground in Shenzhen advanced hospital.

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